6533b7ddfe1ef96bd127512a

RESEARCH PRODUCT

SUBSTRATE-ELICITED DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME P-450 COMPLEX AND THE CONSEQUENTIAL REACTIVATION OF MONOOXYGENATION

James W. BridgesClifford R. ElcombeBrian C. SweatmanMaurice Dickins

subject

BiphenylCytochromebiologyChemistryStereochemistryMetaboliteAlkylationhumanitiesDissociation (chemistry)Hydroxylationchemistry.chemical_compoundIsosafrolebiology.proteinPyrene

description

ABSTRACT The present study was initiated to determine whether the substrate-elicited dissociation of the isosafrole metabolite-cytochrome P-450 complex resulted in increased monooxygenase activity. It was found that the substrates p -nitroanisole and ethoxycoumarin would elicit dissociation, furthermore this dissociation was accompanied by increased dealkylation of the substrates. Benzo(a)pyrene was found not to effect the dissociation of the complex, while biphenyl, which undergoes a similar hydroxylation, was effective.

yearjournalcountryeditionlanguage
1977-01-01
https://doi.org/10.1016/b978-0-08-021523-5.50038-9