6533b833fe1ef96bd129c30a

RESEARCH PRODUCT

LC-QTOF-MS and 1H NMR Metabolomics Verifies Potential Use of Greater Omentum for Klebsiella pneumoniae Biofilm Eradication in Rats

Marzenna BartoszewiczPiotr MłynarzWojciech MiltykJoanna TeulAdam ZąbekDanuta SmutnickaJerzy PałkaAdam JunkaStanislaw DejaPiotr BarćKatarzyna Celińska-janowicz

subject

Microbiology (medical)Klebsiella pneumoniae<i>Klebsiella pneumoniae</i>implantslcsh:Medicinemacromolecular substancesArticleMicrobiologysurgery03 medical and health sciencesmicrobial biofilm eradication0302 clinical medicinePeritoneummedicineMetabolomeImmunology and Allergy030212 general & internal medicineMolecular BiologyGeneral Immunology and Microbiologybiologyintegumentary systembusiness.industrylcsh:RBiofilmGreater omentumbiology.organism_classificationAntimicrobialmetabolomicsbody regionsKlebsiella pneumoniaeInfectious Diseasesmedicine.anatomical_structureImplantbusinessWound healing030217 neurology & neurosurgery

description

Bacterial wound infections are a common problem associated with surgical interventions. In particular, biofilm-forming bacteria are hard to eradicate, and alternative methods of treatment based on covering wounds with vascularized flaps of tissue are being developed. The greater omentum is a complex organ covering the intestines in the abdomen, which support wound recovery following surgical procedures and exhibit natural antimicrobial activity that could improve biofilm eradication. We investigated changes in rats&rsquo

yearjournalcountryeditionlanguage
2020-05-01Pathogens
10.3390/pathogens9050399http://dx.doi.org/10.3390/pathogens9050399