Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

6533b833fe1ef96bd129c3df

RESEARCH PRODUCT

Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

Gaetano Dattolo Antonino Lauria Patrizia Diana Girolamo Cirrincione Anna Maria Almerico Paola Barraja

subject

Antitumor activity Drug Temozolomide Chemistry Stereochemistry media_common.quotation_subject Pharmaceutical Science Biological activity Pharmacology Heterocyclic Compounds 2-Ring In vitro D-1 Dacarbazine Drug Discovery Temozolomide medicine Antineoplastic Agents Alkylating medicine.drug media_common

description

The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug.

year	journal	country	edition	language
2000-08-05	Il Farmaco

https://doi.org/10.1016/s0014-827x(00)00022-7

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