6533b833fe1ef96bd129c41b

RESEARCH PRODUCT

Active behaviour during early development shapes glucocorticoid reactivity.

Soojin RyuLuis A. Castillo-ramírezRodrigo J. De MarcoRodrigo J. De Marco

subject

0301 basic medicineReflex StartleEmbryo NonmammalianCentral nervous systemDaniolcsh:MedicineNeurophysiologyBiologyArticle03 medical and health sciences0302 clinical medicineStress PhysiologicalDevelopmental biologymedicineAnimalslcsh:ScienceReactivity (psychology)ZebrafishGlucocorticoidsSwimmingZebrafishQLMultidisciplinaryEffectorlcsh:Rfungibiology.organism_classification030104 developmental biologymedicine.anatomical_structurelcsh:QNeurophysiology ; Developmental biologyAdaptationNeuroscience030217 neurology & neurosurgeryFunction (biology)Glucocorticoidmedicine.drug

description

AbstractGlucocorticoids are the final effectors of the stress axis, with numerous targets in the central nervous system and the periphery. They are essential for adaptation, yet currently it is unclear how early life events program the glucocorticoid response to stress. Here we provide evidence that involuntary swimming at early developmental stages can reconfigure the cortisol response to homotypic and heterotypic stress in larval zebrafish (Danio rerio), also reducing startle reactivity and increasing spontaneous activity as well as energy efficiency during active behaviour. Collectively, these data identify a role of the genetically malleable zebrafish for linking early life stress with glucocorticoid function in later life.

yearjournalcountryeditionlanguage
2019-03-20Scientific reports
10.1038/s41598-019-49388-3https://pubmed.ncbi.nlm.nih.gov/31488853