6533b833fe1ef96bd129caa5

RESEARCH PRODUCT

Über «therapeutische» und «toxische» Digitoxigeninwirkungen auf elektrophysiologische Messgrössen des Meerschweinchenvorhofs

subject

description

‘Therapeutic’ concentrations of digitoxigenin (10−7−3× 10−7 g/ml), producing positive inotropic effects, did not alter resting and action potentials of electrically driven guinea-pig auricles. However, ‘toxic’ concentrations of digitoxigenin (5 × 10−7−10−8 g/ml), producing arrhythmias and contracture of the myocardium, had a marked influence upon resting and action potentials and conduction velocity.