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RESEARCH PRODUCT
ChemInform Abstract: 1,2-Methyl Shift in the Reaction of 4,7-Dihydro-4,5-dimethyl-7-phenyl-(1,2,4)-triazolo[1,5-a]pyrimidine with Tosyl Azide.
V. D. OrlovHerbert MeierSergey A. KomykhovAlexander S. KaganovskySergey M. Desenkosubject
PyrimidineStereochemistryChemistrychemistry.chemical_elementGeneral MedicineCarbon-13 NMRNitrogenMedicinal chemistryAdductEnamineTosyl azidechemistry.chemical_compoundDerivative (chemistry)Methyl groupdescription
The reaction of the heterocyclic enamine 1 with tosyl azide (2) leads to the tosylimino derivative 4 of 1,2,4-triazolo[1,5-a]pyrimidine. The extrusion of nitrogen from the primary adduct 3 is followed by a 1,2-shift of a methyl group. The structure determination of 4 is based on 1H and 13C nmr spectra including NOE measurements.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-07 | ChemInform |