6533b834fe1ef96bd129cc9e
RESEARCH PRODUCT
Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions
Sergio RosselliMaurizio BrunoVenera CardileSebastiano DelfineCarmen FormisanoFelice SenatoreAlessandra RussoDaniela Riganosubject
Chromatography GasAntineoplastic AgentsToxicologyMass SpectrometryBorneollaw.inventionchemistry.chemical_compoundCamphorfoodlawCell Line TumorBotanyOils VolatileHumansSalvia officinalisEssential oilbiologyTraditional medicineSclareolSAGESalvia officinalisGeneral Medicinebiology.organism_classificationfood.foodchemistryOfficinalisSalvia aethiopisFood Sciencedescription
Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient in food industry. Sage essential oil is applied in the treatment of a range of diseases and has been shown to possess different biological activities. The objectives of our research were to study the effects of environment on crop, chemical composition and anticancer activity on S. officinalis essential oil. Sage was cultivated at eighteen experimental sites in south-central Italy (Molise) in different growing environments. The essential oils (S1-S18), extracted by hydrodistillation, were analyzed by GC and CG/MS. Results show that the main components were α-thujone, camphor, borneol, γ-muurolene and sclareol for all the samples, but the percentages of these compounds varied depending on environmental factors such as altitude, water availability and pedo-climatic conditions. The growth-inhibitory and proapoptotic effects of the eighteen sage essential oils were evaluated in three human melanoma cell lines, A375, M14, and A2058.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | Food and Chemical Toxicology |