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RESEARCH PRODUCT
Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder
Steven C. BakkerAndreas WarnkeJames T. MccrackenEdmund J.s. Sonuga-barkeEdmund J.s. Sonuga-barkeEdmund J.s. Sonuga-barkeAna MirandaF. Xavier CastellanosMaximilian MuenkeAlysa E. DoyleSandra K. LooFernando MulasFrancisco LoperaAnke HinneyEmma Van Der MeulenBarbara FrankeBarbara FrankeDavid PinedaSusanne WalitzaAstrid DempfleSusan L. SmalleyJames J. McgoughMichael GillPaola ForaboscoHerbert RoeyersJenny EkholmMarcel RomanosStephen V. FaraoneStephen V. FaraoneRobert D. OadesKlaus-peter LeschMauricio Arcos-burgosMauricio Arcos-burgosKaixin ZhouTobias J. RennerTobias BanaschewskiAndreas ReifJohannes HebebrandJobst MeyerJan K. BuitelaarThuy Trang NguyenRichard J. SinkeJoseph BiedermanRichard P. EbsteinCathryn M. LewisEric MickMatthew N. OgdieStanley F. NelsonPhilip AshersonHans-christoph SteinhausenJuan David PalacioChristian JacobJoseph A. SergeantSusann FriedelChristine M. FreitagAribert RothenbergerHelmut Schäfersubject
Genetics and epigenetic pathways of disease [NCMLS 6]Genetic LinkageEuropean Continental Ancestry GroupMedizinGenome ScanBiologyNeuroinformatics [DCN 3]Mental health [NCEBP 9]Genetic determinismWhite PeopleArticleChromosomesGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineGene mappingCognitive neurosciences [UMCN 3.2]Genetic linkageGenetic predispositionmedicinePerception and Action [DCN 1]Attention deficit hyperactivity disorderHumansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersGenetics (clinical)030304 developmental biologyProbabilityLinkage (software)Genetics0303 health sciencesGenomeGenome HumanPair 16Chromosome Mappingmedicine.diseasePsychiatry and Mental healthGenetic defects of metabolism [UMCN 5.1]Attention Deficit Disorder with HyperactivityMeta-analysisLod ScoreFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryChromosomes Human Pair 16Humandescription
Contains fulltext : 69243.pdf (Publisher’s version ) (Closed access) Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-12-05 | American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics |