6533b834fe1ef96bd129cd5e

RESEARCH PRODUCT

DNA-binding of zinc(II) and nickel(II) salphen-like complexes extrapolated at 1 M salt concentration: Removing the ionic strength bias in physiological conditions

Giuseppe GennaroClaudio MiglioreRiccardo BonsignoreGiampaolo BaroneGianluca Farine

subject

Absorption spectroscopyInorganic chemistryStatic ElectricitySalt (chemistry)chemistry.chemical_elementRelative weightZincPhenylenediaminesSodium Chloride010402 general chemistry01 natural sciencesBiochemistryInorganic ChemistryMetalchemistry.chemical_compoundIonic strengthCoordination ComplexesNickelSalphenchemistry.chemical_classification010405 organic chemistryChemistrySpectrum AnalysisOsmolar ConcentrationDNA0104 chemical sciencesNickelZincIonic strengthSettore CHIM/03 - Chimica Generale E Inorganicavisual_artvisual_art.visual_art_mediumUV–visible absorptionDNA

description

Abstract The DNA-binding of two salphen-like metal complexes of nickel(II) (1) and zinc(II) (2) was investigated in different ionic strength solutions by absorption spectroscopy. The data analysis allowed us to obtain the values of their extrapolated DNA-binding constant in physiological conditions, with DNA-binding strength in the order Ni > Zn, and to give relative weight to the electrostatic and non-electrostatic contributions to their DNA-interaction.

yearjournalcountryeditionlanguage
2020-01-30Journal of Inorganic Biochemistry
10.1016/j.jinorgbio.2020.111064http://dx.doi.org/10.1016/j.jinorgbio.2020.111064