6533b834fe1ef96bd129ce76

RESEARCH PRODUCT

Cellular immune activation in Sardinian middle-aged, older adults and centenarians

Luca DeianaCalogero CarusoRoberta SerraGianfranco PintusCiriaco CarruArduino A. MangoniAngelo ZinelluSalvatore Sotgia

subject

Male0301 basic medicineAgingImmunosenescenceLongevityInflammationBiologyNeopterinBiochemistryMonocytes03 medical and health scienceschemistry.chemical_compoundEndocrinologyImmune systemGeneticCentenariansGeneticsmedicineHumansMacrophageCentenarianCytokineMolecular BiologyAgedSettore MED/04 - Patologia GeneraleAged 80 and overMacrophagesPteridinesMonocyteAge FactorsNeopterinCell BiologyImmunosenescenceMacrophage ActivationMiddle AgedInflammaging030104 developmental biologymedicine.anatomical_structureItalychemistryImmunologyCohortPteridineCytokinesBiomarker (medicine)FemaleInflammation Mediatorsmedicine.symptomBiomarkers

description

In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects in the 95-year-old group with the highest values. Notably, the group of centenarians had neopterin values comparable to those of 80- and 90-year-old groups, and significantly lower than that of 95-year-old group. This suggests a decreased monocyte/macrophage-mediated immune activation and an apparently preserved immune status in centenarians.

yearjournalcountryeditionlanguage
2017-12-01Experimental Gerontology
https://doi.org/10.1016/j.exger.2017.10.005