Association of body mass index with COVID-19 related in-hospital death.

6533b834fe1ef96bd129cebe

RESEARCH PRODUCT

Association of body mass index with COVID-19 related in-hospital death.

Jason Bouziotis Marianna Arvanitakis Jean-charles Preiser Ali Abbas Sheryl Ann Abdukahil Nurul Najmee Abdulkadir Ryuzo Abe Laurent Abel Lara Absil Subhash Acharya Andrew Acker Shingo Adachi Elisabeth Adam Diana Adrião Saleh Al Ageel Shakeel Ahmed Quratul Ain Kate Ainscough Tharwat Aisa Jan-erik Berdal Susanne Gjeruldsen Dudman Anne Ma Dyrhol-riise Linda Gail Skeie Lars Heggelund Liv Hesstvedt Jan Cato Holter Synne Jenum Simreen Kaur Johal Anders Benjamin Kildal Gry Klouman Bekken Andreas Lind Fredrik Müller Karl Erik Muller Frank O. Pettersen Else Quist Paulsen Dag Henrik Reikvam Aleksander Rygh Holten Vegard Skogen Birgitte Stiksrud Kristian Tonby

subject

Male Adult Nutrition and Dietetics COVID-19 Middle Aged Overweight Critical Care and Intensive Care Medicine Body Mass Index Thinness Diabetes Mellitus Type 2 Risk Factors Humans Female Hospital Mortality Aged

description

Background: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19. Methods: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. Results: Data from 12,137 patients (age 60.0 ± 16.2 years, 59% males, BMI 29.4 ± 6.9 kg/m2 ) of 48 countries were available. By univariate analysis, underweight patients had a higher risk of mortality than the other patients (sub-hazard ratio (SHR) 1.75 [1.44e2.14]). Mortality was lower in normal (SHR 0.69 [0.58e0.85]), overweight (SHR 0.53 [0.43e0.65]) and obese (SHR 0.55 [0.44e0.67]) than in underweight patients. Multivariable analysis (adjusted for age, chronic pulmonary disease, malignant neoplasia, type 2 diabetes) confirmed that in-hospital mortality of underweight patients was higher than overweight patients (females: SHR 0.63 [0.45e0.88] and males: 0.69 [0.51e0.94]). Conclusion: Even though these findings do not imply changes in the medical care of hospitalized patients, they support the use of BMI category for the stratification of patients enrolled in interventional studies where mortality is recorded as an outcome.

year	journal	country	edition	language
2022-01-29	Clinical nutrition (Edinburgh, Scotland)

10.1016/j.clnu.2022.01.017 https://pubmed.ncbi.nlm.nih.gov/35123821