Association analyses identify 31 new risk loci for colorectal cancer susceptibility

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RESEARCH PRODUCT

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Pj Law M Timofeeva C Fernandez-rozadilla P Broderick J Studd J Fernandez-tajes S Farrington V Svinti C Palles G Orlando A Sud A Holroyd S Penegar E Theodoratou P Vaughan-shaw H Campbell L Zgaga C Hayward A Campbell S Harris Ij Deary J Starr L Gatcombe M Pinna S Briggs L Martin E Jaeger A Sharma-oates J East S Leedham R Arnold E Johnstone H Wang D Kerr R Kerr T Maughan R Kaplan N Al-tassan K Palin Ua Hänninen T Cajuso T Tanskanen J Kondelin E Kaasinen A-p Sarin Jg Eriksson H Rissanen P Knekt E Pukkala P Jousilahti V Salomaa S Ripatti A Palotie L Renkonen-sinisalo A Lepistö J Böhm J-p Mecklin Dd Buchanan A-k Win J Hopper Me Jenkins Nm Lindor Pa Newcomb S Gallinger D Duggan G Casey P Hoffmann Mm Nöthen K-h Jöckel Df Easton Pdp Pharoah J Peto F Canzian A Swerdlow Ra Eeles Z Kote-jarai K Muir N Pashayan Consortium A Harkin K Allan J Mcqueen J Paul T Iveson M Saunders K Butterbach J Chang-claude M Hoffmeister H Brenner I Kirac P Matošević P Hofer S Brezina A Gsur Jp Cheadle La Aaltonen I Tomlinson Rs Houlston Mg Dunlop

subject

Male Science Inheritance Patterns cancer genetics /Datasets as Topic colorectal cancer Genome-wide association studies Polymorphism Single Nucleotide Article White People Asian People Risk Factors Cancer genomics Humans Genetic Predisposition to Disease lcsh:Science Cancer genetics neoplasms cancer genomics Q genomiikka Middle Aged Colorectal cancer digestive system diseases peräsuolisyöpä syöpägeenit Genetic Loci Case-Control Studies genome-wide association studies lcsh:Q syöpätaudit Female Colorectal Neoplasms Genome-Wide Association Study

description

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

year	journal	country	edition	language
2019-05-14	Nature Communications

10.1038/s41467-019-09775-w https://doaj.org/article/70e8e953edd64bddb89636d55f3bc15c