6533b834fe1ef96bd129d5a7

RESEARCH PRODUCT

Synthetic biology: Engineered stable ecosystems

Alfonso JaramilloAlfonso JaramilloAlfonso Jaramillo

subject

0301 basic medicineMicrobiology (medical)Gene CircuitsEcology[SDV]Life Sciences [q-bio]ImmunologyCell BiologyBiologyApplied Microbiology and BiotechnologyMicrobiology03 medical and health sciencesSynthetic biology030104 developmental biology0302 clinical medicineGeneticsEcosystem030217 neurology & neurosurgeryEcosystem levelComputingMilieux_MISCELLANEOUSStable state

description

International audience; Co-culture of bacterial cells engineered with quorum-sensing and self-lysis circuits allows coupled oscillatory dynamics and stable states, opening the way to engineered microbial ecosystems with targeted dynamics and extending gene circuits to the ecosystem level.

10.1038/nmicrobiol.2017.119https://hal-cea.archives-ouvertes.fr/cea-01887541