6533b834fe1ef96bd129d70d

RESEARCH PRODUCT

Steroidal saponins from the aerial parts of Cordyline fruticosa L. var. strawberries.

Beaudelaire Kemvoufo PonouMassimo BramucciLuciano BarboniAzefack Léon TapondjouRémy Bertrand TeponnoMarie-aleth Lacaille-duboisLuana Quassinti

subject

Cordyline fruticosaCordylineStereochemistryPhytochemicalsBreast AdenocarcinomaMass spectrometrychemistry.chemical_compoundSulfationColon carcinomaCell Line TumorDrug DiscoveryHumansCameroonCytotoxicityPharmacologybiologyMolecular StructurePhytosterolsGeneral MedicinePlant Components AerialSaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicchemistryTwo-dimensional nuclear magnetic resonance spectroscopyDerivative (chemistry)

description

A new sulfated steroidal derivative (fruticogenin A: 1-sulfo-australigenin-3-sodium sulphate, 1) and three new steroidal saponins named fruticoside K (3-sulfo-spirostan-25(27)-ene-1β,3β-diol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 2), fruticoside L (3-sulfo-spirostan-25(27)-ene-1β,3β,6α-triol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 3) and fruticoside M (spirostan-25(27)-ene-1β,3α-diol-1-O-[α-L-rhamnopyranosyl-(1 → 2)-α-L-rhamnopyranoside], 4) were isolated from the aerial parts of Cordyline fruticosa L. var. strawberries. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. Compounds 2 and 4 exhibited weak cytotoxicity against melanoma (A375), breast adenocarcinoma (MDA-MB-231), and colon carcinoma (HCT116) human tumor cell lines.

yearjournalcountryeditionlanguage
2019-04-01Fitoterapia
10.1016/j.fitote.2019.03.019https://pubmed.ncbi.nlm.nih.gov/30910736