6533b834fe1ef96bd129d7cb
RESEARCH PRODUCT
Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles
Volker MailänderVolker MailänderSi WuAndreas BestKristina KrippesShuqing HeSandra RitzHans-jürgen ButtZhijun Chensubject
Materials scienceNear infrared lightMetals and Alloyschemistry.chemical_elementNanotechnologyGeneral ChemistryMesoporous silicaPhotochemistryAnticancer drugCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsRutheniumLight intensitychemistryDrug deliveryMaterials ChemistryCeramics and CompositesUpconverting nanoparticlesOverheating (electricity)description
Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-11-20 | Chemical Communications |