0000000000498639

AUTHOR

Zhijun Chen

showing 2 related works from this author

Upconversion Nanocarriers Encapsulated with Photoactivatable Ru Complexes for Near-Infrared Light-Regulated Enzyme Activity.

2017

Enzyme activity is important for metabolism, cell functions, and treating diseases. However, remote control of enzyme activity in deep tissue remains a challenge. This study demonstrates near-infrared (NIR) light-regulated enzyme activity in living cells based on upconverting nanoparticles (UCNPs) and a photoactivatable Ru complex. The Ru complex is a caged enzyme inhibitor that can be activated by blue light. To prepare a nanocarrier for NIR photoinhibition of enzyme activity, a UCNP and the caged enzyme inhibitors are encapsulated in a hollow mesoporous silica nanoparticle. In such a nanocarrier, the UCNP can harvest NIR light and convert it into blue light, which can activate the caged e…

Materials scienceCell SurvivalInfrared RaysCathepsin KNanoparticle02 engineering and technology010402 general chemistryPhotochemistry01 natural sciencesRutheniumBiomaterialsCell Line TumorLNCaPHumansGeneral Materials ScienceEnzyme Inhibitorsneoplasmschemistry.chemical_classificationbiologytechnology industry and agricultureGeneral ChemistryMesoporous silicaequipment and supplies021001 nanoscience & nanotechnologyPhoton upconversionEnzyme assay0104 chemical sciencesEnzymechemistryEnzyme inhibitorbiology.proteinNanoparticlesNanocarriers0210 nano-technologyBiotechnologySmall (Weinheim an der Bergstrasse, Germany)
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Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

2014

Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.

Materials scienceNear infrared lightMetals and Alloyschemistry.chemical_elementNanotechnologyGeneral ChemistryMesoporous silicaPhotochemistryAnticancer drugCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsRutheniumLight intensitychemistryDrug deliveryMaterials ChemistryCeramics and CompositesUpconverting nanoparticlesOverheating (electricity)Chemical Communications
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