6533b834fe1ef96bd129d8b6

RESEARCH PRODUCT

Age at menopause predicts age at onset of Parkinson's disease.

Graziella CallariPaolo RagoneseMarco D'amelioGiuseppe SalemiGiovanni SavettieriLetterio Morgante

subject

AdultAgingmedicine.medical_specialtyParkinson's diseasePhysiologyDiseaseRisk AssessmentCentral nervous system diseaseDegenerative diseasefertile lifePregnancyRisk FactorsInternal medicineage at menopausemedicineHumansAge of OnsetRisk factorAgedAged 80 and overPregnancybusiness.industryParkinson DiseaseMiddle Agedmedicine.diseaseMenopauseEndocrinologyNeurologyParkinson’s diseaseLinear ModelsSettore MED/26 - NeurologiaFemalewomenNeurology (clinical)MenopauseAge of onsetbusiness

description

We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.

yearjournalcountryeditionlanguage
2006-10-10
http://hdl.handle.net/11570/1889754