6533b834fe1ef96bd129e0b7

RESEARCH PRODUCT

Determination of boron concentration in blood and tissue samples from patients with liver metastases of colorectal carcinoma using Prompt Gamma Ray Activation Analysis (PGAA).

P. KudejovaJ. V. KratzG. HampelK. AppelmanC. SchützTobias SchmitzGerd OttoR. Moss

subject

inorganic chemicalsRadiationbusiness.industryColorectal cancerLiver NeoplasmsGamma raychemistry.chemical_elementHealthy tissuemedicine.diseaseBoron concentrationPharmacokineticschemistryMedicineHumansbusinessBoronNuclear medicineColorectal NeoplasmsBoron

description

As part of the studies on Boron Neutron Capture Therapy at the University of Mainz, Germany, a clinical trial has been started, in which our patients suffering from liver metastases of colorectal carcinoma, have been enrolled. Specimens of blood and healthy tissue samples taken from the patients were measured at the PGAA facilities at the HFR in Petten, The Netherlands, and at the FRM II in Munich, Germany. From the measured boron concentrations, pharmacokinetic curves and blood-to-tissue concentration ratios were produced.

yearjournalcountryeditionlanguage
2010-08-27Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
10.1016/j.apradiso.2011.02.007https://pubmed.ncbi.nlm.nih.gov/21354802