6533b834fe1ef96bd129e0ba

RESEARCH PRODUCT

Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications

Cristina MondelloLuigi CardiaAlessio AsmundoPatrizia GualnieraDaniela SapienzaElvira Ventura SpagnoloSerena Scurria

subject

0301 basic medicinemedicine.medical_specialtyForensic pathologyClinical BiochemistryInfarctionContext (language use)Reviewischemia/reperfusion injury03 medical and health sciences0302 clinical medicineSettore MED/43 - Medicina LegaleInternal medicinemedicine030216 legal & forensic medicineMyocardial infarctioncomplement systemlcsh:R5-920business.industryC5b-9schemia/reperfusion injuryforensic pathologymedicine.diseaseComplement systempost mortem investigation030104 developmental biologymyocardial infarctionInclusion and exclusion criteriaCardiologyC5b-9; complement system; forensic pathology; ischemia/reperfusion injury; myocardial infarction; post mortem investigationbusinessComplement membrane attack complexlcsh:Medicine (General)Reperfusion injury

description

The complement system has a significant role in myocardial ischemia/reperfusion injury, being responsible for cell lysis and amplification of inflammatory response. In this context, several studies highlight that terminal complement complex C5b-9, also known as the membrane attack complex (MAC), is a significant contributor. The MAC functions were studied by many researchers analyzing the characteristics of its activation in myocardial infarction. Here, a systematic literature review was reported to evaluate the principal features, advantages, and limits (regarding the application) of complement components and MAC in post mortem settings to perform the diagnosis of myocardial ischemia/infarction. The review was performed according to specific inclusion and exclusion criteria, and a total of 26 studies were identified. Several methods studied MAC, and each study contributes to defining better how and when it affects the myocardial damage in ischemic/reperfusion injury. The articles were discussed, focusing on the specificity, sensibility, and post mortem stability of MAC as a marker of myocardial ischemia/infarction, supporting the usefulness in routine post mortem investigations.

yearjournalcountryeditionlanguage
2020-11-01
10.3390/diagnostics10110898http://hdl.handle.net/11570/3180069