6533b834fe1ef96bd129e123
RESEARCH PRODUCT
Negative occurrence between hippocampal rhythmic slow activity and epileptiform spikes: Influence of the striatum
V. SavatteriM. SabatinoV. La GruttaG Gravantesubject
Decerebrate StateMedial septal nucleusTime FactorsPhysiologyChemistryCaudate nucleusHippocampusStimulationPenicillinsStriatumHippocampal formationmedicine.diseaseHippocampusBiochemistryCorpus StriatumElectrophysiologyEpilepsyRhythmmedicine.anatomical_structureCatsmedicineAnimalsCaudate NucleusNeurosciencedescription
AbstractThe effects of caudate and septal stimulation on hippocampal activity were studied. Sodium penicillin was intravenously injected in order to induce a steady rate of in-terictal epileptic activity. Penicillin injection caused significant reduction of the rate of occurrence and duration of hippocampal rhythmic slow activity (RSA). Spontaneous RSA as well as RSA-eliciting caudate and septal stimulation induced a marked inhibition on frequency of epileptiform complexes. Lesions of the medial septal nucleus made it impossible to record RSA or to observe any sort of influence on hippocampal epileptiform activity by caudate stimulation. This result suggests that the septum is important for RSA genesis in the striato-hippocampal pathway or in the reciprocal septo-hippocampal connections.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-12-01 | Archives Internationales de Physiologie et de Biochimie |