6533b834fe1ef96bd129e187

RESEARCH PRODUCT

Fifteen Shades of Grey: Combined Analysis of Genome-Wide SNP Data in Steppe and Mediterranean Grey Cattle Sheds New Light on the Molecular Basis of Coat Color

Gabriele SenczukLorenzo GuerraSalvatore MastrangeloClaudia CampobassoKaouadji ZoubeydaMeghelli ImaneDonata MarlettaSzilvia KuszaTaki KarsliSemir GaouarFabio PillaElena CianiThe Bovita Consortium

subject

0301 basic medicineCandidate geneCoatGenotypelcsh:QH426-470cattle coat color hair greying pigmentation selection signatures SNPsBiologyBreedingGenomePolymorphism Single Nucleotideselection signaturesArticle03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoQuantitative Trait HeritableGenotypeGeneticsAnimalsGene Regulatory NetworkspigmentationSelection GeneticHair ColorGeneGenetics (clinical)AllelesGenetic Association Studiescoat colorGenomeDichromatismGene Expression Profiling0402 animal and dairy science04 agricultural and veterinary sciences040201 dairy & animal sciencePhenotypelcsh:Genetics030104 developmental biologyPhenotypeEvolutionary biologycattleCattle; Coat color; Hair greying; Pigmentation; Selection signatures; SNPshair greyingSNP arrayGenome-Wide Association StudySNPs

description

Coat color is among the most distinctive phenotypes in cattle. Worldwide, several breeds share peculiar coat color features such as the presence of a fawn pigmentation of the calf at birth, turning over time to grey, and sexual dichromatism. The aim of this study was to search for polymorphisms under differential selection by contrasting grey cattle breeds displaying the above phenotype with non-grey cattle breeds, and to identify the underlying genes. Using medium-density SNP array genotype data, a multi-cohort FST-outlier approach was adopted for a total of 60 pair-wise comparisons of the 15 grey with 4 non-grey cattle breeds (Angus, Limousin, Charolais, and Holstein), with the latter selected as representative of solid and piebald phenotypes, respectively. Overall, more than 50 candidate genes were detected

yearjournalcountryeditionlanguage
2020-08-13Genes
10.3390/genes11080932http://dx.doi.org/10.3390/genes11080932