6533b834fe1ef96bd129e19e
RESEARCH PRODUCT
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever
G VitaleS MansuetoG GambinoC MocciaroC La RussaP MansuetoM A L ZambitoV FerlazzoC BarberaM La RosaS MilanoE Cillarisubject
AdultMaleImmunologyIntercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1BiologyBoutonneuse FeverPathogenesisLeukocyte CountmedicineHumansImmunology and AllergyL-SelectinCell adhesionAgedAnalysis of VarianceCell adhesion moleculeMiddle AgedIntercellular Adhesion Molecule-1medicine.diseasebiology.organism_classificationUp-RegulationEndothelial stem cellBoutonneuse feverSolubilityImmunologyLinear ModelsCytokinesFemaleOriginal ArticleE-SelectinRickettsia conoriiSelectindescription
SUMMARYIn 150 patients with Boutonneuse fever (BF), caused by Rickettsia conorii, we studied the plasma levels of soluble l-selectin (s l-selectin), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) in various phases of disease to clarify their role in disease evolution. Results indicate that during the acute phase of BF there is a significant increase in the serum levels of s l-selectin, sE-selectin, sVCAM-1 and sICAM-1. s l-selectin and sVCAM-1 returned to normal levels in the third week of disease, whereas sE-selectin and sICAM-1 persisted at significantly high levels even after the third week. The secretion of these soluble CAMs in BF is mainly the result of leucocyte expression and endothelial cell activation, but secretion also appears to mediate anti-inflammatory activities, moderating leucocyte adhesion and reducing in particular lymphocyte and monocyte infiltration. Only s l-selectin serum levels were found to correlate with the acute phase of infection characterized by fever.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-08-12 | Clinical and Experimental Immunology |