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RESEARCH PRODUCT
Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease
N. SinagraDaniela CoronaPierfrancesco VerouxCecilia GozzoStefano PalmucciD. ZerboLuca MamminoPaolo MurabitoMassimiliano VerouxAlessia GiaquintaDaniele Caltabianosubject
Malemedicine.medical_treatment030232 urology & nephrology030204 cardiovascular system & hematologyKidneyPathology and Laboratory MedicineNephrectomyVascular MedicineDiagnostic Radiology0302 clinical medicineChronic Kidney DiseaseMedicine and Health SciencesRenal TransplantationPolycystic kidney diseaseMedicineProspective StudiesTomographyKidney transplantationPolycystic Kidney DiseasesKidneyMultidisciplinaryRadiology and ImagingQROrgan SizeMiddle AgedMagnetic Resonance ImagingNephrectomyTreatment Outcomemedicine.anatomical_structureNephrologyMedicineFemaleAnatomymedicine.symptomResearch Articlemedicine.medical_specialtyImaging TechniquesScienceUrologySurgical and Invasive Medical ProceduresHemorrhageNeuroimagingKidney VolumeResearch and Analysis MethodsAsymptomaticUrinary System Procedures03 medical and health sciencesSigns and SymptomsDiagnostic MedicineMedical DialysisHumansTransplantationSurgical Excisionurogenital systembusiness.industryBiology and Life SciencesKidneysRenal SystemOrgan Transplantationmedicine.diseaseKidney TransplantationComputed Axial TomographyTransplantationbusinessFollow-Up StudiesNeuroscienceBilateral Nephrectomydescription
BackgroundThe indication to bilateral nephrectomy in patients with autosomal dominant polycystic kidney scheduled for kidney transplantation is controversial. Indeed, the progressive enlargement of cysts may increase the risk of complications and the need for nephrectomy. However, very few studies investigated the change in kidney volume after kidney transplantation.Material and methodsIn this prospective cohort study, the change in native kidney volume in polycystic patients was evaluated with magnetic resonance imaging. Forty patients were included in the study. Kidney diameters and total kidney volume were evaluated with magnetic resonance imaging in patients who underwent simultaneous nephrectomy and kidney transplantation and in patients with kidney transplant alone, before transplantation and 1 year after transplantation.ResultsThere was a significant reduction of kidney volume after transplantation, with a mean degree of kidney diameters reduction varying from 12.24% to 14.43%. Mean total kidney volume of the 55 kidney considered in the analysis significantly reduced from 1617.94 ± 833.42 ml to 1381.42 ± 1005.73 ml (PConclusionsPolycystic kidneys volume significantly reduces after kidney transplantation, and this would reduce the need for prophylactic bilateral nephrectomy in asymptomatic patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-12 | PLOS ONE |