6533b835fe1ef96bd129e9c1
RESEARCH PRODUCT
Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich
Anja SchüfflerGabin Thierry M. BitchagnoGabin Thierry M. BitchagnoMatthias KrumbTill OpatzIngrid Konga SimoPierre Tanesubject
biologyTraditional medicine010405 organic chemistryChemistryMicroorganismOrganic ChemistryPlant ScienceAsteraceaebiology.organism_classificationAntimicrobialIsolation (microbiology)01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistryCell cultureCancer cell linesCytotoxicityBacteriadescription
Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the isolated compounds were evaluated in the Hela-S3 cell line and in a panel of microorganisms (bacteria and fungi) at concentrations up to 50 µg/mL. The new compounds were inactive while the pentamethylated flavonoids showed low to significant activity against the cancer cell line used. However, none of the samples showed any activity against the tested microorganisms at this concentration. The present manuscript is the first investigation of the cytotoxicity of phytochemicals and extract from C. pyrrhopappa.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-15 | Natural Product Research |