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RESEARCH PRODUCT

Vitamin D, allergies and asthma: focus on pediatric patients

Auro Della GiustinaGiuseppe PingitoreMassimo LandiMarzia OnorariGiuliana FerranteGiovanni PassalacquaSalvatore TripodiAlessandro TravagliniM. BosoniFederica Bellini

subject

lcsh:Immunologic diseases. AllergyPulmonary and Respiratory MedicineAllergymedicine.medical_specialtyPediatricsSupplementationSettore MED/10 - Malattie dell'Apparato RespiratorioImmunologyAlternative medicinePediatric allergyReviewBone healthVitamin D allergic diseases immunomodulation suppplementation asthma rhinitis pediatric allergyImmunomodulationSettore MED/38 - Pediatria Generale E SpecialisticaFood allergymedicineVitamin D and neurologyImmunology and AllergyVitamin DVitamin D; Allergic diseases; Immunomodulation; Supplementation; Asthma; Rhinitis; Pediatric allergyAsthmaRhinitisVitamin d supplementationbusiness.industryAllergic diseasesAllergic diseases; Asthma; Immunomodulation; Pediatric allergy; Rhinitis; Supplementation; Vitamin DAtopic dermatitismedicine.diseaseAsthmaImmunologylcsh:RC581-607business

description

In recent years, the interest of the scientific world towards vitamin D gradually increased, and several studies have been conducted to dissect its possible role in modulating the development/course of allergic diseases. Also, Vitamin D supplementation has been assessed as a beneficial approach for treating allergies in some, but not all studies. We reviewed herein the available and relevant literature concerning the possible links between Vitamin D, its supplementation and allergic diseases. A literature search was made independently by the Authors, identifying articles for a narrative review. As per literature, Vitamin D plays a key role in calcium and phosphate metabolism, and it is essential for bone health in infants, children and adolescents. However, there is presently insufficient evidence to support vitamin D supplementation for prevention or treatment of allergic diseases in infants, children and adolescents, concerning allergic rhinitis, asthma, food allergy and atopic dermatitis. Keywords: Vitamin D, Allergic diseases, Immunomodulation, Supplementation, Asthma, Rhinitis, Pediatric allergy

10.1186/1939-4551-7-27http://dx.doi.org/10.1186/1939-4551-7-27