6533b835fe1ef96bd129eb01

RESEARCH PRODUCT

Ovulation induction and epigenetic anomalies

Patricia Fauque

subject

Infertilitymedicine.medical_specialtyReproductive Techniques Assistedmedicine.medical_treatmentBiologyBioinformaticsEpigenesis GeneticMiceOvulation InductionInternal medicinemedicineAnimalsHumansEpigeneticsEpigenesisGenetic Diseases InbornObstetrics and Gynecologymedicine.diseaseEndocrinologyReproductive MedicineModels AnimalDNA methylationFemaleOvulation inductionGenomic imprintingReprogrammingHormone

description

In this systematic review of ovulation induction and epigenetic control, studies mainly done in the mouse model highlight how hormone treatments may be prejudicial to the epigenetic reprogramming of gametes as well as early embryos. Moreover, the hormone protocols used in assisted reproduction may also modify the physiologic environment of the uterus, a potential link to endometrial epigenetic disturbances. At present, the few available data in humans are insufficient to allow us to independently determine the impact of a woman's age and infertility problems and treatment protocols and hormone doses on such processes as genomic imprinting.

yearjournalcountryeditionlanguage
2013-03-01Fertility and Sterility
https://doi.org/10.1016/j.fertnstert.2012.12.047