6533b835fe1ef96bd129eb12

RESEARCH PRODUCT

N-Terminal amino acid sequence analysis indicates that isolated atrial amyloid is derived from atrial natriuretic peptide

Franz S. StörkelClaudia VoigtManfred EulitzReinhold P. Linke

subject

AmyloidAmyloidFormic acidMolecular Sequence DataSize-exclusion chromatographyIsolated atrial amyloidHigh-performance liquid chromatographyPathology and Forensic Medicinechemistry.chemical_compoundAtrial natriuretic peptidechemistryBiochemistrymental disordersHumansNIPFemaleAmino Acid SequencePeptide sequenceAtrial Natriuretic FactorAged

description

Isolated atrial amyloid, the most frequent senile cardiac amyloid type, was chemically analysed. Amyloid fibrils obtained from a patient (NIP) were extracted and the predominant low-molecular-weight polypeptide (approximately 3.5 kDa, designated ASc2 NIP) was isolated by size exclusion high performance liquid chromatography in 60% formic acid. N-Terminal amino acid sequence analysis of this polypeptide was identical to that of the atrial natriuretic peptide alpha-hANP for the first 12 residues determined.

yearjournalcountryeditionlanguage
1988-11-01Virchows Archiv B Cell Pathology
https://doi.org/10.1007/bf02896569