6533b835fe1ef96bd129eb31

RESEARCH PRODUCT

Pyridylcarbene formation by thermal decomposition of 7-bromo-3-methyl-[1,2,3]triazolo[1,5-a]pyridine under pressure

Belén AbarcaRafael BallesterosFernando Blanco

subject

High pressure reactionEthanolPyridylcarbeneUNESCO::QUÍMICA:QUÍMICA::Química orgánica [UNESCO]Organic ChemistryThermal decompositionchemistry.chemical_element:QUÍMICA [UNESCO]Medicinal chemistryNitrogenlcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistrychemistryTriazolopyridines decompositionPyridinePyridylcarbene ; High pressure reaction ; Triazolopyridines decompositionOrganic chemistryUNESCO::QUÍMICA::Química orgánicaCarbene

description

7-Bromo-3-methyl-[1,2,3]triazolo[1,5-a]pyridine 1 at 1.7 atm and 100ºC decompose to form a pyridylcarbene intermediate by nitrogen expulsion. The carbene stabilization give 2-bromo-6- vinylpyridine 2, 1-(6-bromopyridin-2-yl)ethanol 3, 1-(6-Bromopyridin-2-yl)ethanone 4, 2- bromo-6-[2-(6-bromopyridin-2-yl)-2-methyl-trans-cyclopropyl]pyridine 5, and 2-bromo-6-[2-(6- bromopyridin-2-yl)-2-methyl-cis-cyclopropyl]pyridine 6. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es

yearjournalcountryeditionlanguage
2007-01-01Arkivoc
https://doi.org/10.3998/ark.5550190.0008.426