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RESEARCH PRODUCT

Guidance on allergenicity assessment of genetically modified plants

Efsa Panel On Genetically Modified Organisms (Gmo)Hanspeter NaegeliAndrew Nicholas BirchJosep CasacubertaAdinda De SchrijverMikolaj Antoni GralakPhilippe GuercheHuw JonesBarbara ManachiniAntoine MesséanElsa Ebbesen NielsenFabien NoguéChristophe RobagliaNils RostoksJeremy SweetChristoph TebbeFrancesco VisioliJean‐michel WalPhilippe EigenmannMichelle EpsteinKarin Hoffmann‐sommergruberFrits KoningMartinus LovikClare MillsFrancisco Javier MorenoHenk Van LoverenRegina SelbAntonio Fernandez Dumont

subject

allergenicity assessmentVeterinary (miscellaneous)[SDV]Life Sciences [q-bio]newly expressed proteinsPlant ScienceGenetically modified cropsTP1-1185010501 environmental sciencesBiology01 natural sciencesMicrobiologyBiosafety0404 agricultural biotechnologyProtein digestibilityguidance; allergenicity assessment; newly expressed proteins; endogenous allergenicity; GMOTX341-6410105 earth and related environmental sciences2. Zero hungerbusiness.industryGMONutrition. Foods and food supplyChemical technology10079 Institute of Veterinary Pharmacology and Toxicology04 agricultural and veterinary sciencesFood safetyendogenous allergenicity040401 food science3. Good healthBiotechnologyScientific OpinionSettore AGR/11 - Entomologia Generale E Applicata570 Life sciences; biologynewly expressed proteinAnimal Science and ZoologyParasitologyImmune reactionbusinessRisk assessmentguidanceFood Science

description

Abstract This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non‐IgE‐mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate.

yearjournalcountryeditionlanguage
2017-06-01
10.2903/j.efsa.2017.4862https://hal.archives-ouvertes.fr/hal-01605253/file/Naegeli_et_al-2017-EFSA_Journal_1.pdf