Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase

6533b835fe1ef96bd129ebb5

RESEARCH PRODUCT

Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase

Franz Oesch Helmut Thomas Anders Rane Lucio Giuliani G. M. Pacifici A. Temellini

subject

Valpromide medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Sodium chemistry.chemical_element In Vitro Techniques Biology Toxicology Cytosol Fetus Pregnancy Internal medicine Stilbenes medicine Humans Epoxide hydrolase Epoxide Hydrolases Kidney Valproic Acid General Medicine Cytosol Anticonvulsant Endocrinology medicine.anatomical_structure Liver chemistry Enzyme inhibitor Toxicity biology.protein Anticonvulsants Female medicine.drug

description

The effect of the antiepileptics valpromide and sodium valproate on the cytosolic epoxide hydrolase was studied in human fetal liver, kidneys and adrenals and from human adult liver and kidneys. Trans-stilbene oxide was used as substrate. Valpromide (10 mM) lowered the activity of the epoxide hydrolase to one half of the control in all organs studied. Sodium valproate (10 mM) was less powerful as an inhibitor than valpromide; however, it exerted a significant inhibition in all tissues studied.

year	journal	country	edition	language
1989-04-01	Archives of Toxicology

https://doi.org/10.1007/bf00316440

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