6533b835fe1ef96bd129ec2b

RESEARCH PRODUCT

Vitamin B12 and hepatic enzyme serum levels correlate in male alcohol-dependent patients.

Christoph KlaweIon AnghelescuHubertus HimmerichArmin Szegedi

subject

AdultErythrocyte IndicesMalemedicine.medical_specialtyCarbohydrate deficient transferrinAspartate transaminaseStatistics NonparametricGlutamate DehydrogenaseInternal medicineBlood plasmamedicineHumansCyanocobalaminVitamin B12Aspartate AminotransferasesLiver Diseases AlcoholicRetrospective StudiesbiologyGlutamate dehydrogenaseTransferrinnutritional and metabolic diseasesAlanine TransaminaseGeneral Medicinegamma-GlutamyltransferaseMiddle AgedAlcoholismVitamin B 12EndocrinologyAlanine transaminaseLiverToxicitybiology.proteinBiomarkers

description

- Vitamin B12 serum levels and markers for alcohol consumption were determined in 80 male alcohol-dependent patients. Spearman correlation coefficients (r(S)) were calculated. Significant positive correlations between vitamin B12 and hepatic enzyme values were found (gamma-glutamyltransferase: r(S) = 0.58; alanine aminotransferase: r(S) = 0.43; aspartate aminotransferase: r(S) = 0.47; glutamate dehydrogenase: r(S) = 0.43; all P:0.001). Therefore, for a proper interpretation of vitamin B12 levels, it may be clinically relevant to take markers of hepatocellular damage into account.

yearjournalcountryeditionlanguage
2001-01-05Alcohol and alcoholism (Oxford, Oxfordshire)
10.1093/alcalc/36.1.26https://pubmed.ncbi.nlm.nih.gov/11139412