6533b835fe1ef96bd129ed64
RESEARCH PRODUCT
Production of polymeric micro- and nanostructures with tunable properties as pharmaceutical delivery systems
Gennara CavallaroSalvatore Emanuele DragoEmanuela Fabiola CraparoGaetano Giammonasubject
NanostructureMaterials sciencePolymers and PlasticsMicrofluidicsNanoparticlemacromolecular substances02 engineering and technology010402 general chemistry01 natural sciencesPEG ratioMaterials ChemistryCopolymerOrganic Chemistrytechnology industry and agricultureαβ-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA)equipment and suppliesmusculoskeletal system021001 nanoscience & nanotechnologyCondensation reactionGrafting0104 chemical sciencesGraft copolymerChemical engineeringMicrofluidicMicroparticlePoly-ε-caprolactone (PCL)Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoNanoparticles0210 nano-technologyNanoprecipitationdescription
Abstract The production of novel graft copolymers based on poly-e-caprolactone (PCL) and polyaspartamide are useful to realize structures for potential biomedical applications. Here, the synthesis of pegylated PCL/polyhydroxyethyl aspartamide (PHEA) graft copolymers (PHEA-g-SUCC-PCL-g-PEG) with tunable composition, was achieved by followpling a synthetic strategy that involved first the grafting of preformed PCL on PHEA backbone, then polyethylen glycol (PEG), by using 1,1′-carbonyldiimidazole (CDI) to speed up the condensation reaction. Graft copolymers with a Derivatization Degree (DD) in PCL ranging between 1.1 and 4.4 mol% were obtained, and processable with different technologies for the realization of micro- and nanostructures for biomedical applications. Pegylated graft copolymers, PHEA-g-SUCC-PCL-g-PEG, with a DDPEG of about 3.9 mol% were synthesized, and starting from these materials, structures such as fibers, micro- and nanoparticles were produced by different methods, such as microfluidics and nanoprecipitation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-01 |