Search results for "Nanoprecipitation"
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Production of polymeric micro- and nanostructures with tunable properties as pharmaceutical delivery systems
2020
Abstract The production of novel graft copolymers based on poly-e-caprolactone (PCL) and polyaspartamide are useful to realize structures for potential biomedical applications. Here, the synthesis of pegylated PCL/polyhydroxyethyl aspartamide (PHEA) graft copolymers (PHEA-g-SUCC-PCL-g-PEG) with tunable composition, was achieved by followpling a synthetic strategy that involved first the grafting of preformed PCL on PHEA backbone, then polyethylen glycol (PEG), by using 1,1′-carbonyldiimidazole (CDI) to speed up the condensation reaction. Graft copolymers with a Derivatization Degree (DD) in PCL ranging between 1.1 and 4.4 mol% were obtained, and processable with different technologies for t…