Entwicklung von Tyrosinkinase-Inhibitoren bei hämatologischen Neoplasien. FLT3 und JAK2 als therapeutischeTargets

6533b835fe1ef96bd129f35a

RESEARCH PRODUCT

Entwicklung von Tyrosinkinase-Inhibitoren bei hämatologischen Neoplasien. FLT3 und JAK2 als therapeutischeTargets

Daniel B. Lipka Thomas Fischer Christoph Huber Florian Heidel

subject

Pharmacology Gynecology medicine.medical_specialty business.industry medicine Pharmaceutical Science Pharmacology (medical)Hematologic Neoplasms business Tyrosine kinase

description

Tyrosinkinase-Inhibitoren stellen einen wichtigen Beitrag zur Weiterentwicklung und Verbesserung der Therapie von hamatologischen Neoplasien dar. Zahlreiche Inhibitoren befinden sich bereits in fortgeschrittener klinischer Testung. Wahrend bei einem Teil der Erkrankungen (CML) die Inhibitor-Therapie bereits als Standard etabliert ist, befinden sich die “small molecules” bei Akuter Myeloischer Leukamie und chronisch-myeloproliferativen Syndromen noch in der Etablierungsphase. Die Entwicklung von neuen zielgerichteten Substanzen zahlt zu den grosen praklinischen und klinischen Herausforderungen der nachsten Jahre.

year	journal	country	edition	language
2008-09-01	Pharmazie in unserer Zeit

https://doi.org/10.1002/pauz.200800280

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