Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

6533b835fe1ef96bd129f585

RESEARCH PRODUCT

Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

Antonio Ferrer-montiel María J. Vicent Ismael Mingarro Isabel Masip Angel G. Martin Enrique Pérez-payá Howard O. Fearnhead Angel Messeguer Glòria Sanclimens Gema Malet Mar Orzáez

subject

Multiprotein complex Cytochrome Protein-protein interactions Apoptosis Caspase 3 Mitochondrion Ligands Cell Line Chemical library chemistry.chemical_compound Peptide Library Apoptosomes Peptoid Humans Combinatorial libraries inhibitor Apoptosome Protein Precursors Molecular Biology biology Caspase 3 Intrinsic apoptosis Cytochromes c Cell Biology Caspase Inhibitors Caspase 9 Recombinant Proteins Mitochondria Cell biology Enzyme Activation Caspasa-9 Apoptotic Protease-Activating Factor 1 chemistry Biochemistry N-substituted Glycines Apoptosis Caspasa-3 biology.protein Apoptosome Apaf-1 Molecular recognition Small molecule Protein Binding

description

10 pages, 5 figures.-- PMID: 16341125 [PubMed].-- Available online Dec 9, 2005.

year	journal	country	edition	language
2006-01-01	Cell Death & Differentiation

https://doi.org/10.1038/sj.cdd.4401828

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