Search results for "Apaf-1"

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Solitary Fibrous Tumor: Integration of Clinical, Morphologic, Immunohistochemical and Molecular Findings in Risk Stratification and Classification Ma…

2021

Although solitary fibrous tumors (SFTs) have an unpredictable evolution, some specific clinicopathologic factors have been associated with the final outcome. We retrieved clinical, pathological and molecular data of 97 patients with a histological diagnosis of SFT and Signal transducer and activator of transcription 6 (STAT6) positivity. We retrospectively studied the pathological factors predictive of recurrence/metastasis and compared them with the clinical outcome. A wide immunohistochemical study and molecular analysis to detect NAB2/STAT6 gene fusion, tumor protein-53 (TP53) and/or (telomerase reverse transcriptase) TERT promotor mutation were performed. The risk of metastasis was calc…

MalePathologymedicine.medical_specialtySolitary fibrous tumorQH301-705.5CD99CD34APAF-1Risk AssessmentArticleCatalysisMetastasisInorganic ChemistryBiomarkers TumormedicineHumanssolitary fibrous tumorTelomerase reverse transcriptaseBiology (General)risk stratification systemsPhysical and Theoretical ChemistryQD1-999Molecular BiologyPathological<i>p53</i> mutationSpectroscopyRetrospective StudiesSTAT6<i>HTER</i> mutationbusiness.industryOrganic ChemistrySoft tissueGeneral MedicineMiddle AgedPrognosismedicine.diseaseCombined Modality TherapyImmunohistochemistryp53 mutationComputer Science ApplicationsChemistryHTER mutationSolitary Fibrous TumorsImmunohistochemistryFemaleNeoplasm Recurrence LocalbusinessFollow-Up StudiesInternational Journal of Molecular Sciences
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Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

2006

10 pages, 5 figures.-- PMID: 16341125 [PubMed].-- Available online Dec 9, 2005.

Multiprotein complexCytochromeProtein-protein interactionsApoptosisCaspase 3MitochondrionLigandsCell LineChemical librarychemistry.chemical_compoundPeptide LibraryApoptosomesPeptoidHumansCombinatorial libraries inhibitorApoptosomeProtein PrecursorsMolecular BiologybiologyCaspase 3Intrinsic apoptosisCytochromes cCell BiologyCaspase InhibitorsCaspase 9Recombinant ProteinsMitochondriaCell biologyEnzyme ActivationCaspasa-9Apoptotic Protease-Activating Factor 1chemistryBiochemistryN-substituted GlycinesApoptosisCaspasa-3biology.proteinApoptosomeApaf-1Molecular recognitionSmall moleculeProtein BindingCell Death &amp; Differentiation
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