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RESEARCH PRODUCT
Solitary Fibrous Tumor: Integration of Clinical, Morphologic, Immunohistochemical and Molecular Findings in Risk Stratification and Classification May Better Predict Patient outcome
Javier LaverniaAntonio Llombart-boschFrancisco GinerAntonio FerrándezIsidro MachadoSamuel NavarroJulia CruzMaría Gema Nieto Moralessubject
MalePathologymedicine.medical_specialtySolitary fibrous tumorQH301-705.5CD99CD34APAF-1Risk AssessmentArticleCatalysisMetastasisInorganic ChemistryBiomarkers TumormedicineHumanssolitary fibrous tumorTelomerase reverse transcriptaseBiology (General)risk stratification systemsPhysical and Theoretical ChemistryQD1-999Molecular BiologyPathological<i>p53</i> mutationSpectroscopyRetrospective StudiesSTAT6<i>HTER</i> mutationbusiness.industryOrganic ChemistrySoft tissueGeneral MedicineMiddle AgedPrognosismedicine.diseaseCombined Modality TherapyImmunohistochemistryp53 mutationComputer Science ApplicationsChemistryHTER mutationSolitary Fibrous TumorsImmunohistochemistryFemaleNeoplasm Recurrence LocalbusinessFollow-Up Studiesdescription
Although solitary fibrous tumors (SFTs) have an unpredictable evolution, some specific clinicopathologic factors have been associated with the final outcome. We retrieved clinical, pathological and molecular data of 97 patients with a histological diagnosis of SFT and Signal transducer and activator of transcription 6 (STAT6) positivity. We retrospectively studied the pathological factors predictive of recurrence/metastasis and compared them with the clinical outcome. A wide immunohistochemical study and molecular analysis to detect NAB2/STAT6 gene fusion, tumor protein-53 (TP53) and/or (telomerase reverse transcriptase) TERT promotor mutation were performed. The risk of metastasis was calculated using the Demicco risk stratification system (RSS). The results were combined and examined to assess the accuracy of risk stratification and classification. The most common location was in non-extremities
year | journal | country | edition | language |
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2021-08-30 | International Journal of Molecular Sciences |