An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia.

6533b835fe1ef96bd129f5bc

RESEARCH PRODUCT

An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia.

Anja Thiede Paula Virtala Kaija Mikkola Minna Huotilainen Iina Ala-kurikka Paavo H.t. Leppänen Eino Partanen Eino Partanen Teija Kujala

subject

6162 Cognitive science Male Speech sound Audiology Event-related potential (ERP)Dyslexia 0302 clinical medicine EARLY LANGUAGE-ACQUISITION newborn Medicine FAMILIAL RISK Auditory BRAIN RESPONSES 05 social sciences event-related potential (ERP)Electroencephalography Sensory Systems Language development Neurology Laterality Evoked Potentials Auditory Speech Perception Female Analysis of variance speech sound psychological phenomena and processes medicine.medical_specialty 515 Psychology MISMATCH NEGATIVITY MMN CORTICAL RESPONSES EVENT-RELATED POTENTIALS GENETIC RISK behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Speech discrimination Event-related potential Phonetics Physiology (medical)Vowel otorhinolaryngologic diseases dysleksia Humans Speech 0501 psychology and cognitive sciences auditory AUDITORY-DISCRIMINATION Mismatch response (MMR)vastasyntyneet Auditory Cortex business.industry puheääni 3112 Neurosciences Dyslexia Infant Newborn Newborn mismatch response (MMR)medicine.disease ta3124 Pseudoword PHONEME MISMATCH Acoustic Stimulation DEVELOPMENTAL DYSLEXIA Neurology (clinical)business 030217 neurology & neurosurgery

description

Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk. Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA. Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls. Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination. Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. Peer reviewed

year	journal	country	edition	language
2019-05-01	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

10.1016/j.clinph.2019.01.019 https://pubmed.ncbi.nlm.nih.gov/30870799