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RESEARCH PRODUCT
Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidative stress and essential metal concentration in lead exposed male Wistar rats
Erkki KolehmainenAmjad AliBernard MahieuGeetu SaxenaChebrolu P. RaoSwaran J.s. Florasubject
Blood PlateletsMaleMagnetic Resonance SpectroscopyStereochemistrychemistry.chemical_elementReversal Of Lead Toxicity In Wistar RatsAbsorption (skin)Hepatic And Renal Soft Tissuemedicine.disease_causeBiochemistryMedicinal chemistryInorganic ChemistryMetalSpectroscopy Mossbauerchemistry.chemical_compoundSpectroscopy Fourier Transform InfraredMössbauer spectroscopyOrganotin CompoundsmedicineAnimalsRats WistarStrain (chemistry)Tetranuclear Tin ComplexesChemistryHematological ParametersRatsOxidative StressMatrix-assisted laser desorption/ionizationLeadTinSpectrometry Mass Matrix-Assisted Laser Desorption-Ionizationvisual_artvisual_art.visual_art_mediumCalixarenesTinDerivative (chemistry)Oxidative stressdescription
The two Sn(IV) complexes synthesized using calix[4]arene-1,3-di-acid derivative were characterized by analytical, 1H, 13C and 119Sn NMR, matrix assisted laser desorption ionization mass, and 119Sn Mossbauer techniques and found that the complexes are tetranuclear possessing structurally two different types of tin centers. These complexes were evaluated for their protective value against blood and tissue oxidative stress in lead exposed male albino rats of Wistar strain. The results suggest that the two tin complexes significantly protect changes in lead induced biochemical variables indicative of heme synthesis pathway and exhibit only moderate effect on tissue oxidative stress. The beneficial effects could be attributed mainly to the ability of Sn(IV) complexes in preventing absorption of lead to the target sites/tissues.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-08-12 | Journal of Inorganic Biochemistry |