6533b835fe1ef96bd12a001f
RESEARCH PRODUCT
The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy.
Albrecht M. ClementMaximilian G. ChristChristian Behlsubject
0301 basic medicineSigma-1 receptorbiologyGeneral NeuroscienceNeurodegenerationAutophagyNeurodegenerative Diseasesmedicine.diseaseCell biology03 medical and health sciences030104 developmental biology0302 clinical medicineProteostasisChaperone (protein)biology.proteinmedicineAutophagyProteostasisHumansReceptors sigmaReceptor030217 neurology & neurosurgerydescription
Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-01 | Trends in neurosciences |