6533b836fe1ef96bd12a082c
RESEARCH PRODUCT
false
Brigitta SchmidtHelmut RingsdorfKarel Ulbrichsubject
chemistry.chemical_compoundBlood serumchemistryPolymer chemistrySide chainCopolymerMethacrylamideAmine gas treatingDrug carrierOligomerN-(2-Hydroxypropyl) methacrylamidedescription
Drug carriers were prepared by combining oligopeptidic sequences with synthetic polymeric chains. Soluble copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) were synthesized containing oligopeptidic side chains terminating in a drug model (p-nitroaniline). The susceptibility of these oligopeptidic sequences to degradation on incubation with lysosomal enzymes and human serum was evaluated by monitoring the p-nitroaniline liberation. It was shown that the drug model can be attached to the polymer carrier by means of an oligopeptidic spacer stable in blood serum and degradable after the polymer has been in contact with intracellular lysosomal enzymes. The studied polymer carriers were used for binding an anticancer drug, bis(2-chloroethyl)amine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-02-01 | Die Makromolekulare Chemie |