6533b836fe1ef96bd12a08e0
RESEARCH PRODUCT
Regulatory identification of BPA as an endocrine disruptor : Context and methodology
Claude EmondJean-philippe AntignacChristophe MinierJean-nicolas OrmsbySakina Mhaouty-kodjaMartine Kolf-clauwClaire BeausoleilLauranne Verines-jouinFlorence EustacheRené HabertCécile ChevrierJean-pierre CravediFrançois PouzaudLuc P. BelzuncesCatherine ViguiéChristophe RousselleHenri SchroederBrigitte Le Magueresse-battistoniMarie-chantal Canivenc-lavierMartine ApplanatPatrick ThonneauCécile MichelLuc MultignerNicolas ChevalierBrice M. R. AppenzellerRémy BeaudouinElodie PasquierElisabeth Elefantsubject
0301 basic medicineendocrine systemBrain developmentpertubateur endocrinienEndocrine disruptionContext (language use)Computational biologyMESH: Social Control Formal010501 environmental sciencesBiologyEndocrine Disruptors01 natural sciencesBiochemistryMammary gland developmentbisphenol A;endocrine disruption;ED;SVHC;substance of very high concern;REACh03 medical and health sciencesEndocrinologyBisphenol AMESH: PhenolsPhenolsSubstance of very high concernMESH: Benzhydryl CompoundsFood and Nutritionbisphénol aAnimalsHumansBenzhydryl CompoundsMolecular BiologyComputingMilieux_MISCELLANEOUSSVHC0105 earth and related environmental sciencesEndocrinology and metabolismurogenital systemsubstance toxiqueED3. Good healthSocial Control FormalMESH: Endocrine Disruptors030104 developmental biologyEndocrine disruptor[SDV.TOX]Life Sciences [q-bio]/ToxicologyAlimentation et NutritionEndocrinologie et métabolismeREACHIdentification (biology)description
International audience; BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies, the analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-01 |