6533b836fe1ef96bd12a0930
RESEARCH PRODUCT
Regional glucose uptake and protein synthesis in isolated perfused rat hearts immediately after training and later
Veikko VihkoVeikko VihkoJyrki KomulainenJyrki KomulainenHeikki KainulainenHeikki KainulainenTimo Takalasubject
Malemedicine.medical_specialtyTime FactorsPhysiologyPhenylalanineGlucose uptakeMuscle ProteinsPhysical exercisePhenylalanineCitrate (si)-SynthaseIn Vitro TechniquesBiologyPhysical Conditioning AnimalPhysiology (medical)Internal medicineMale ratsmedicineProtein biosynthesisAnimalsControl levelMusclesMyocardiumBody WeightHeartRats Inbred StrainsMetabolismRatsPerfusionGlucosemedicine.anatomical_structureEndocrinologyVentricleCardiology and Cardiovascular Medicinedescription
The effect of 10 weeks of running training and termination of training on the regional distribution of cardiac glucose uptake and protein synthesis were studied in isolated perfused hearts in male rats. The left ventricular glucose uptake in hearts from sedentary rats was 1.87 +/- 0.14 mumol/min per g protein (mean +/- SE), being about 30% higher in the subendocardial than in the subepicardial layer (p less than 0.05). The gradient of left ventricular glucose uptake was similar to the controls in the rats retired from training, but was absent in the trained animals. The altered transmural glucose uptake probably reflects differences in the adaptive response of various myocardial muscle layers to a long-term intermittent increase in cardiac work load. Phenylalanine incorporation was evenly distributed through the left ventricle in all the groups, but was lowered in the left and right ventricles of the trained rats. Phenylalanine incorporation returned to the control level 5 weeks after the cessation of training.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-01-01 | Basic Research in Cardiology |