6533b836fe1ef96bd12a0a70
RESEARCH PRODUCT
Correction of the unfavourable effects of vasopressin by nitroglycerin infusion
G. CastronovoV. LanzaA. CaliI. Demmasubject
Vasopressinmedicine.medical_specialtyTime FactorsCentral Venous PressureVasopressinsPortal venous pressureBlood PressureNitroglycerinDogsOxygen ConsumptionHeart RateAnesthesiologyAnimalsMedicineInfusions Parenteralcardiovascular diseasesAdverse effectNitroglycerinbusiness.industryGeneral MedicineVenous Blood PressuresAnesthesiology and Pain MedicineAnesthesiacardiovascular systembusinesscirculatory and respiratory physiologymedicine.drugdescription
Nitroglycerin was administered with vasopressin to prevent adverse effects. Vasopressin 0.25U . 70 kg-1 min-1 was infused intravenously in four dogs for 40 minutes, when a venous infusion of nitroglycerin 1.2 micrograms . kg-1 . min-1 was added for 20 minutes. Nitroglycerin 1.2 micrograms . kg-1 . min-1 alone was infused intravenously in another four dogs for 40 minutes. The venous blood pressures (mesenteric and central) and arterial pressures (mesenteric and femoral), the electrocardiogram and arterio-venous difference were recorded. Nitroglycerin was shown to annul the unfavourable effects of vasopressin without altering its efficacy upon portal pressure.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1982-05-01 | Canadian Anaesthetists’ Society Journal |