6533b836fe1ef96bd12a0ad1

RESEARCH PRODUCT

Effects of physical training on metabolism of connective tissues in young mice.

subject

description

The effects of physical training on the metabolism of collagen, calcium and glycosaminoglycans in various connective tissues were studied in male NMRI mice. The mice to be trained and their controls were about 3 weeks old (expt. I) and 8 weeks old (expt. II) at the commencement of training. The training was performed on a 5 degree inclined treadmill 5 days a week for 4 weeks in expt. I and for 3 weeks in expt. II. The daily exercise time was progressively increased from 20 min in the first week up to 80 min in the third week. The incorporation of 3H-proline to collagen hydroxyproline was increased by training in long bones, skeletal muscle and Achilles tendon, whereas the incorporation of 35S-sulphate into glycosaminoglycans of bones was lower for the trained compared to the control mice. The differences between the two groups in the incorporation of 45calcium were negligible. The results indicate that the metabolism of collagen is accelerated by physical training in several connective tissues in young rapidly growing mice, whereas the metabolism of glycosaminoglycans remains uneffected or is even retarded.