6533b836fe1ef96bd12a0b78

RESEARCH PRODUCT

Immunohistochemical and morphological characteristics of tissues response to polylactic acid membranes with silver nanoparticles

Eugenia KoganIrina Vyacheslavovna IvanovaMargarita GevandovaLeonid Leonidovich BorozdkinElena Alexandrovna ShalamovaG. A. DemyashkinTatyana DemuraZelimhan CentroevSergey KalininVlada Smirnova-sotmari

subject

Bone RegenerationSilverPolyestersMetal NanoparticlesNanoparticleSilver nanoparticleColloidchemistry.chemical_compoundPolylactic acidFibrosismedicineAnimalsBone regenerationGeneral DentistryOral Medicine and PathologyChemistryResearchCapsulemedicine.disease:CIENCIAS MÉDICAS [UNESCO]MembraneOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASSurgeryRabbitsBiomedical engineering

description

Background The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations. Material and Methods We assessed colloid solution-derived silver nanoparticles coating of polylactic acid membrane regarding tissue foreign body response. Thirty eight polylactic acid membranes were implanted intracranially in rabbits – ten unmodified (control group) and twenty eight with silver nanoparticles coating (experimental group). In controls, penicillin was used for infection prophylaxis. Tissue response was assessed by light microscopy and immunohistochemistry (CD3, CD15, CD30) 2 weeks after implantation. Results inflammation markers in experimental group were significantly lower than in control group, there were no signs of forming a fibrosis capsule nor infectious signs. Conclusions colloid silver solution can be used as a source of nanoparticles for anti-microbial and anti-inflammatory biodegradable membranes’ coating. Key words:Guided bone regeneration, polylactic acid membrane, silver nanoparticles.

https://hdl.handle.net/10550/77078