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RESEARCH PRODUCT
Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes.
Marcos MeseguerBegoña VallejoA. CoelloEva SanchezAna CoboJosé Remohísubject
0301 basic medicineAdultCell SurvivalEmbryonic DevelopmentBiologyAndrologyEmbryo Culture Techniques03 medical and health sciences0302 clinical medicineHuman fertilizationOvulation InductionPregnancymedicineHumansBlastocystFormation rateSurvival rateRetrospective StudiesCryopreservation030219 obstetrics & reproductive medicineEmbryogenesisObstetrics and GynecologyEmbryoOocyteEmbryo TransferVitrification030104 developmental biologymedicine.anatomical_structureReproductive MedicineOocytesFemaleDevelopmental Biologydescription
Abstract Research question Does the presence of dysmorphisms affect post-warming survival and embryo development in vitrified autologous oocytes? Design A retrospective study comparing post-warming survival, fertilization and embryo development between morphologically normal (n = 269) and dysmorphic oocytes (n = 147). Results The survival rate was 81.4% in the morphologically normal oocytes and 87.1% in the dysmorphic oocyte group (OR 1.53; 95% CI 0.86 to 2.72). The fertilization rate was 69.9 versus 66.4% (OR 0.85; 95% CI 0.53 to 1.36), the proportion of good-quality embryos on day 3 was 30.3% versus 32.0% (OR 1.08; 95% CI 0.59 to 1.97) and the blastocyst formation rate was 54.5% versus 60.5% (OR 1.27; 95% CI 0.60 to 2.72) for the morphologically normal and the dysmorphic oocytes group, respectively. No statistical differences were found when the number and type of dysmorphism were analysed. Conclusion Oocyte dysmorphisms did not seem to affect survival, fertilization and embryo development in vitrified autologous oocytes, and yielded comparable results to the morphologically normal oocytes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-03-01 | Reproductive biomedicine online |