6533b836fe1ef96bd12a0bf2
RESEARCH PRODUCT
Sarcopenia, frailty and their prevention by exercise.
Marta InglésC.m. NascimentoAndrea Salvador-pascualMari Carmen Gomez-cabreraJose ViñaMárcia Regina Cominettisubject
0301 basic medicineGerontologySarcopeniaNutritional SupplementationFrailty syndromePsychological interventionBiochemistry03 medical and health sciences0302 clinical medicineAtrophyPhysiology (medical)medicineAnimalsHumansExerciseAgedFrailtybusiness.industryMalnutritionmusculoskeletal systemmedicine.diseaseMalnutritionOxidative Stress030104 developmental biologySarcopeniaDietary SupplementsOlder peoplebusinesshuman activities030217 neurology & neurosurgerydescription
Sarcopenia is a major component of the frailty syndrome, both being considered as strong predictors of morbidity, disability, and death in older people. In this review, we explore the definitions of sarcopenia and frailty and summarize the current knowledge on their relationship with oxidative stress and the possible therapeutic interventions to prevent or treat them, including exercise-based interventions and multimodal strategies. We highlight the relevance of the impairment of the nervous system and of the anabolic response (protein synthesis) in muscle aging leading to frailty and sarcopenia. We also discuss the importance of malnutrition and physical inactivity in these geriatric syndromes. Finally, we propose multimodal interventions, including exercise programs and nutritional supplementation, as the strategies to prevent and treat both sarcopenia and frailty.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-01 | Free radical biologymedicine |