6533b836fe1ef96bd12a11b6

RESEARCH PRODUCT

Hyperbranched poly(glycolide) copolymers with glycerol branching points via ring-opening copolymerization

Anna M. FischerChristoph SchüllHolger Frey

subject

Materials sciencePolymers and PlasticsComonomerOrganic ChemistryBiodegradable polymerRing-opening polymerizationPolyesterchemistry.chemical_compoundEnd-groupMonomerchemistryPolymer chemistryMaterials ChemistryCopolymerOrganic chemistryTwo-dimensional nuclear magnetic resonance spectroscopy

description

Abstract Sn(Oct) 2 -catalyzed synthesis of hyperbranched poly(glycolide) copolymers with glycerol branching points in the backbone is possible via ring-opening multi-branching copolymerization (ROMBP) of glycolide and 5HDON (5-hydroxymethyl-1,4-dioxan-2-one). Using this strategy, well-defined and soluble branched polyesters with apparent molecular weights (M n ) in the range of 1300–2000 g mol −1 and varying comonomer content (5HDON/glycolide = 30:70–70:30) were obtained. 2D NMR spectroscopy, thermal analysis and MALDI-TOF mass spectrometry confirmed the successful incorporation of both monomers and the resulting branched structure. Multiple end group functionality offers the possibility for further post-polymerization modification, rendering the materials interesting with respect to processing of PGA. Potential applications range from novel polyurethanes to biomedical purposes.

yearjournalcountryeditionlanguage
2015-08-01Polymer
https://doi.org/10.1016/j.polymer.2015.04.047