6533b836fe1ef96bd12a11cf
RESEARCH PRODUCT
¿Es real el riesgo de osteoporosis y riesgo de fracturas con el uso crónico de inhibidores de la bomba de protones?
Juan V. EspluguesMiguel Marti-masanetMiguel Martí-cabrerasubject
Gynecologymedicine.medical_specialtyHepatologybusiness.industryOsteoporosisGastroenterologymedicine.diseaseIntestinal absorptionDisease susceptibilityClinical evidencemedicineMalabsorption syndromesbusinessPotential toxicitydescription
Proton pump inhibitors (PPI) are one of the most widely used groups of drugs and their potential toxicity is periodically reviewed, emphasizing aspects originally considered secondary. The present review analyzes the physiological and pharmacological bases and the scarce clinical evidence for a potential association between the continued administration of PPI and the development of osteoporosis and bone fractures. Both disorders are clearly related to calcium homeostasis and are highly important in elderly patients due to their poor general prognosis and disabling consequences.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-04-01 | Gastroenterología y Hepatología |